Protective effects of sodium beta-aescin on ischemia-reperfusion injury in rat brain / 药学学报
Acta Pharmaceutica Sinica
;
(12): 419-423, 2004.
Article
in English
| WPRIM
| ID: wpr-302795
ABSTRACT
<p><b>AIM</b>To investigate the protective effects of sodium beta-aescin on cerebral ischemia-reperfusion injury in rats.</p><p><b>METHODS</b>Rats were pretreated with sodium beta-aesein for 7 d and then subjected to cerebral ischemia-reperfusion injury induced by a middle cerebral artery occlusion (MCAO). The neurological outcome was evaluated by the Longa's method; The infarct volume was assessed by hemmatoxylin-Eosin staining and the cerebral water content was measured by dry weight method. The activities of SOD, GSH-Px, CAT, Na+ -K+ -ATPase and the MDA content were measured in the cortex and hippocampus of ischemic and non-ischemic hemisphere.</p><p><b>RESULTS</b>Sodium beta-aescin significantly reduced the volume of cerebral infarct and water content, and ameliorated the neurological deficit (P < 0.05). In vehicle-treated rats, the activities of SOD, GSH-Px and Na+ -K+ -ATPase in the cortex and hippocampus of ischemic hemisphere were all decreased (P < 0.01) , while the CAT activity was slightly elevated and the MDA of content was significantly increased (P < 0.01) compared with the sham-operated group. After treated with sodium beta-aescin, the effects on recovery of SOD, GSH-Px, Na+ -K+ -ATPase activities were observed (P < 0.05), and the MDA content was reduced (P < 0.05).</p><p><b>CONCLUSION</b>These results showed that pretreatment with sodium beta-aescin can attenuate brain injury and its antioxidant activity on rats which encountered cerebral ischemia-reperfusion.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Superoxide Dismutase
/
Brain
/
Reperfusion Injury
/
Catalase
/
Brain Ischemia
/
Rats, Sprague-Dawley
/
Sodium-Potassium-Exchanging ATPase
/
Neuroprotective Agents
Limits:
Animals
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2004
Type:
Article
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