Neuroendocrine neoplasm of digestive system with different grades: a clinicopathologic and prognostic study / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 448-451, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-303550
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic and prognostic features of neuroendocrine neoplasm of digestive system with different grades.</p><p><b>METHODS</b>The clinicopathologic features of 139 cases of neuroendocrine neoplasm occurring in digestive system were retrospectively reviewed and graded according to the 2010 World Health Organization classification of tumours of the digestive system. Immunohistochemical study for synaptophysin, chromogranin A and Ki-67 was carried out. The follow-up and survival data were analysed using Kaplan-Meier method. Prognostic factors were tested by Log-rank testing and independent risk factors were analysed using Cox regression model.</p><p><b>RESULTS</b>Amongst the 139 cases studied, there were 88 cases (63.3%) of grade 1 tumors, 9 cases (6.5%) of grade 2 tumors and 42 cases (30.2%) of grade 3 tumors. There was diffusely positive staining for synaptophysin and chromogranin A in most of the grade 1 and grade 2 tumors. The staining in grade 3 tumors however was focal (P < 0.05). The differences in tumor size, depth of invasion, presence of tumor emboli, perineural permeation, nodal involvement, distant metastasis and survival rate amongst the three groups was statistically significant (P < 0.05).</p><p><b>CONCLUSIONS</b>There is significant difference in the clinicopathologic and prognostic features of neuroendocrine neoplasm of digestive system with different grades. It is considered as an independent prognostic factor and represents a useful tool for prognostic evaluation of such tumors, both in clinical practice and research.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Proportional Hazards Models
/
Survival Rate
/
Retrospective Studies
/
Follow-Up Studies
/
Synaptophysin
/
Neuroendocrine Tumors
/
Ki-67 Antigen
/
Tumor Burden
/
Digestive System Neoplasms
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2012
Type:
Article
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