Cytotoxicity of methanol extracts of Elaeis guineensis on MCF-7 and Vero cell lines
Asian Pacific Journal of Tropical Biomedicine
;
(12): 826-829, 2012.
Article
in English
| WPRIM
| ID: wpr-303595
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the cytotoxic effect of Elaeis guineensis methanol extract on MCF-7 and Vero cell.</p><p><b>METHODS</b>In vitro cytotoxicity was evaluated in by MTT assay. Cell morphological changes were observed by using light microscope.</p><p><b>RESULTS</b>The MTT assay indicated that methanol extract of the plant exhibited significant cytotoxic effects on MCF-7. Morphological alteration of the cell lines after exposure with Elaeis guineensis extract were observed under phase contrast microscope in the dose dependent manner.</p><p><b>CONCLUSIONS</b>The results suggest the probable use of the Elaeis guineensis methanol extract in preparing recipes for cancer-related ailments. Further studies on isolation of metabolites and their in vivo cytotoxicity are under investigation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Vero Cells
/
Plant Extracts
/
Chlorocebus aethiops
/
Chemistry
/
Plant Leaves
/
Arecaceae
/
Cell Proliferation
/
Methanol
/
Dose-Response Relationship, Drug
Limits:
Animals
/
Humans
Language:
English
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2012
Type:
Article
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