Anti-inflammatory and analgesic activities of Melanthera scandens
Asian Pacific Journal of Tropical Biomedicine
;
(12): 144-148, 2012.
Article
in English
| WPRIM
| ID: wpr-303610
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the anti-inflammatory and analgesic activities of leaf extract of Melanthera scandens (M. scandens).</p><p><b>METHODS</b>The crude leaf extract (39-111 mg/kg) of M. scandens was investigated for anti-inflammatory and analgesic activities using various experimental models. The anti-inflammatory activity was investigated using carragenin, egg-albumin induced oedema models, while acetic acid, formalin-induced paw licking and thermal-induced pain models were used to evaluate the antinociceptive property.</p><p><b>RESULTS</b>The extract caused a significant (P<0.05 - 0.001) dose-dependent reduction of inflammation and pains induced by different agents used.</p><p><b>CONCLUSIONS</b>The leaf extract possesses anti-inflammatory and analgesic effects which may be mediated through the phytochemical constituents of the plant.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain
/
Plant Extracts
/
Carrageenan
/
Plant Leaves
/
Acetic Acid
/
Asteraceae
/
Therapeutic Uses
/
Albumins
/
Drug Therapy
/
Edema
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2012
Type:
Article
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