Inhibition of Ehrlich ascites carcinoma by Manilkara zapota L. stem bark in Swiss albino mice
Asian Pacific Journal of Tropical Biomedicine
;
(12): 448-451, 2011.
Article
in English
| WPRIM
| ID: wpr-303641
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the antitumor activity of Manilkara zapota (M. zapota) L. stem bark against Ehrlich ascites carcinoma (EAC) in Swiss albino mice.</p><p><b>METHODS</b>The in vivo antitumour activity of the ethyl acetate extract of stem bark of M. zapota L. (EASM) was evaluated at 50, 100 and 200 mg/kg bw against EAC using mean survival time. After administration of the extract of M. zapota, viable EAC cell count and body weight in the EAC tumour hosts were observed. The animal was also observed for improvement in the haematological parameters (e.g., heamoglobin content, red and white blood cells count and differential cell count) after EASM treatment.</p><p><b>RESULTS</b>Intraperitoneal administration of EASM reduced viable EAC cells, increased the survival time, and restored altered haematological parameters. Significant efficacy was observed for EASM at 100 mg/kg dose (P<0.05).</p><p><b>CONCLUSIONS</b>It can be concluded that the ethyl acetate extract of stem bark of M. zapota L. possesses significant antitumour activity.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Body Weight
/
Plant Extracts
/
Carcinoma, Ehrlich Tumor
/
Survival Analysis
/
Cell Survival
/
Chemistry
/
Treatment Outcome
/
Plant Bark
/
Manilkara
/
Therapeutic Uses
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2011
Type:
Article
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