Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma
Experimental & Molecular Medicine
;
: e293-2017.
Article
in English
| WPRIM
| ID: wpr-30371
ABSTRACT
Hepatitis B virus (HBV) has an important role in the development of human hepatocellular carcinoma (HCC). Accumulated evidence has shown that HBV-encoded X protein (HBx) can induce both genetic alterations in tumor suppressor genes and oncogenes, as well as epigenetic aberrations in HCC pathogens. Non-coding RNAs (ncRNAs) mainly include microRNAs and long non-coding RNAs (lncRNAs). Although ncRNAs cannot code proteins, growing evidence has shown that they have various important biological functions in cell proliferation, cell cycle control, anti-apoptosis, epithelial–mesenchymal transition, tumor invasion and metastasis. This review summarizes the current knowledge regarding the mechanisms and emerging roles of ncRNAs in the pathogenesis of HBV-related HCC. Accumulated data have shown that ncRNAs regulated by HBx have a crucial role in HBV-associated hepatocarcinogenesis. The findings of these studies will contribute to more clinical applications of HBV-related ncRNAs as potential diagnostic markers or as molecular therapeutic targets to prevent and treat HBV-related HCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Hepatitis B virus
/
Genes, Tumor Suppressor
/
Carcinoma, Hepatocellular
/
RNA, Untranslated
/
MicroRNAs
/
Cell Proliferation
/
Epigenomics
/
Cell Cycle Checkpoints
/
RNA, Long Noncoding
Limits:
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2017
Type:
Article
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