Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis
Experimental & Molecular Medicine
;
: e296-2017.
Article
in English
| WPRIM
| ID: wpr-30373
ABSTRACT
Hippo/YAP signaling is implicated in tumorigenesis and progression of various cancers. By inhibiting a plethora signaling cascades, resveratrol has strong anti-tumorigenic and anti-metastatic activity. In the present study, we demonstrate that resveratrol decreases the expression of YAP target genes. In addition, our data showed that resveratrol attenuates breast cancer cell invasion through the activation of Lats1 and consequent inactivation of YAP. Strikingly, we also demonstrate that resveratrol inactivates RhoA, leading to the activation of Lats1 and induction of YAP phosphorylation. Further, resveratrol in combination with other agents that inactivate RhoA or YAP showed more marked suppression of breast cancer cell invasion compared with single treatment. Collectively, these findings indicate the beneficial effects of resveratrol on breast cancer patients by suppressing the RhoA/Lats1/YAP signaling axis and subsequently inhibiting breast cancer cell invasion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
Breast
/
Breast Neoplasms
/
Carcinogenesis
Limits:
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2017
Type:
Article
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