Factors associated with the efficacy of cardiac resynchronization therapy in patients with chronic heart failure / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 731-735, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-303836
ABSTRACT
<p><b>OBJECTIVE</b>To observe the clinical effects of cardiac resynchronization therapy (CRT) in patients with chronic heart failure, and compare the clinical characteristics and outcome between responders and non-responders to define factors related to the efficacy of CRT.</p><p><b>METHODS</b>We retrospectively analyzed the data of patients underwent CRT-P/D implantation from January 2006 to December 2012 in our Hospital. All patients received long-term follow-up including NYHA classification, left ventricular ejection fraction (LVEF) and left ventricular internal dimension at end diastole (LVIDd).</p><p><b>RESULTS</b>A total of 204 patients were included (130 males, mean age (64.8 ± 11.9) years). The total response rate of CRT was 61.3%. Women, QRS duration ≥ 150 ms, and left bundle branch block (LBBB) were related with better response after CRT (all P < 0.05). Multivariate regression analysis showed that QRS duration was an independent determinant for CRT response. All-cause mortality rate was significantly lower in responder group than in non-responder group (P < 0.001).</p><p><b>CONCLUSIONS</b>In patients with chronic heart failure, women, QRS duration ≥ 150 ms, and LBBB are related with better CRT response rate post CRT. QRS duration ≥ 150 ms is an independent predictor of CRT response, and positive response is associated with lower all-cause mortality in this patient cohort.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Bundle-Branch Block
/
Cardiovascular Diseases
/
Chronic Disease
/
Multivariate Analysis
/
Retrospective Studies
/
Ventricular Function, Left
/
Treatment Outcome
/
Cardiac Resynchronization Therapy
/
Heart Failure
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2014
Type:
Article
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