Advances of circulating biomarkers in gastroenteropancreatic neuroendocrine neoplasms / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 357-360, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-303864
ABSTRACT
Gastroenteropancreatic neuroendocrine neoplam (GEP-NEN) is a rare group of tumors with its incidence rising significantly in recent decades. Because of the late presentation of the disease and limitations in conventional biomarkers, about 50% of GEP-NEN patients manifests advanced disease when diagnosed. Therefore, it is vital to identify circulating biomarkers which can not only be used for early diagnosis but also accurately evaluating the biological behavior of GEP-NEN. This review summarizes the advances of circulating biomarkers in diagnosing and evaluating efficacy of treatment in GEP-NEN. Well-known circulating biomarkers include chromogranin A (CgA), pancreastatin (PST), chromogranin B (CgB), neuron-specific enolase (NSE) and pancreatic peptide(PP). Novel biomarkers including circulating tumor cell(CTC), microRNA and NETest are promising biomarkers with potential clinical benefit, but further researches are needed before their clinical applications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatic Neoplasms
/
Phosphopyruvate Hydratase
/
Blood
/
Pancreatic Polypeptide
/
Biomarkers, Tumor
/
Chemistry
/
Neuroendocrine Tumors
/
MicroRNAs
/
Diagnosis
/
Chromogranin A
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2017
Type:
Article
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