Role of mitogen-activated protein kinase pathway in chloracne / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 154-156, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-303986
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of mitogen-activated protein kinase (MAPK) signal transduction pathway in chloracne.</p><p><b>METHODS</b>Immunohistochemical technique was used to detect the expression of phosphorylated epidermal growth factor receptor (p-EGFR) and p-MAPK proteins in the epithelium of chloracne group and control group.</p><p><b>RESULTS</b>p-EGFR and p-MAPK was found in all chloracne tissues, whereas no expression of p-EGFR and p-MAPK protein was found in control group. In the skin of chloracne patients, p-EGFR was mainly distributed in the membrane and the cytoplasm, especially in the vicinity of membrane; major positive signal of p-MAPK was in core and serosity.</p><p><b>CONCLUSION</b>EGFR and MAPK phosphorylation is found in chloracne tissues. MAPK signal transduction pathway is one important molecular mechanism of chloracne.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
Physiology
/
Mitogen-Activated Protein Kinases
/
MAP Kinase Signaling System
/
Chloracne
/
ErbB Receptors
/
Metabolism
/
Occupational Diseases
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2008
Type:
Article
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