Lipid peroxidation injury and endoplasmic reticulum stress in Al-induced apoptosis / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 143-146, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-303989
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of lipid peroxidation injury and endoplasmic reticulum stress in Al-induced apoptosis.</p><p><b>METHODS</b>Neurons from 0-3 day rats were cultured and treated with different concentrations of AlCl3.6H2O. Morphologic changes of neurons and endoplasmic reticulum were observed under fluorescent and transmission electron microscope; activities of superoxide dismutase (SOD), malondialdehyde (MDA) and ATP enzymes were detected.</p><p><b>RESULTS</b>Typical morphologic changes in neurons apoptosis and endoplasmic reticulum were found under fluorescent and transmission electron microscope; SOD enzyme viability and ATP enzyme viability were significantly increased in the low-dosage group, but reduced in mid and high-dosage group (P < 0.01), whereas MDA levels decreased in the low-dosage group, but increased in mid and high-dosage group (P < 0.01).</p><p><b>CONCLUSION</b>Aluminum may induce neurons apoptosis, and lipid peroxidation injury in endoplasmic reticulum plays an important role in the apoptosis progression.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Lipid Peroxidation
/
Cells, Cultured
/
Rats, Sprague-Dawley
/
Apoptosis
/
Toxicity
/
Aluminum
/
Endoplasmic Reticulum Stress
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2008
Type:
Article
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