The debate on treating subclinical hypothyroidism
Singapore medical journal
;
: 539-545, 2016.
Article
in English
| WPRIM
| ID: wpr-304115
ABSTRACT
Subclinical hypothyroidism (SCH) represents a mild or compensated form of primary hypothyroidism. The diagnosis of SCH is controversial, as its symptoms are non-specific and its biochemical diagnosis is arbitrary. The treatment of SCH was examined among non-pregnant adults, pregnant adults and children. In non-pregnant adults, treatment of SCH may prevent its progression to overt hypothyroidism, reduce the occurrence of coronary heart disease, and improve neuropsychiatric and musculoskeletal symptoms associated with hypothyroidism. These benefits are counteracted by cardiovascular, neuropsychiatric and musculoskeletal side effects. SCH is associated with adverse maternal and fetal outcomes that may improve with treatment. Treating SCH in children is safe and may improve growth. Importantly, the evidence in this field is largely from retrospective and prospective studies with design limitations, which precludes a conclusive recommendation for the treatment of SCH.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pregnancy Complications
/
Therapeutics
/
Blood
/
Bone and Bones
/
Biomarkers
/
Prospective Studies
/
Retrospective Studies
/
Risk Factors
/
Treatment Outcome
/
Disease Progression
Type of study:
Diagnostic study
/
Etiology study
/
Practice guideline
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
English
Journal:
Singapore medical journal
Year:
2016
Type:
Article
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