Effect of sappan wood on perforin mRNA expression in myocardium of rats after allogeneic cardiac transplantation / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 370-372, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-304159
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Sappan wood (SW) on the expression of perforin mRNA in myocardium of rats after allogeneic cardiac transplantation.</p><p><b>METHODS</b>The animal model of allogeneic (abdominal) cardiac transplantation was established by taking Wistar rat as provider and SD rat as receptor, perforin mRNA expression in the model's myocardium was detected by RT-PCR.</p><p><b>RESULTS</b>SW could obviously reduce the perforin mRNA expression, it also could alleviate the pathological morphology and ultrastructural damage of myocardial cells.</p><p><b>CONCLUSION</b>SW has obvious effect in antagonizing immune rejection after transplantation, the mechanism of its immunosuppression could be through lowering the perforin mRNA expression.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Transplantation, Homologous
/
RNA, Messenger
/
Drugs, Chinese Herbal
/
Membrane Glycoproteins
/
Chemistry
/
Heart Transplantation
/
Rats, Wistar
/
Rats, Sprague-Dawley
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2003
Type:
Article
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