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Effect of astragalus injection on immune function in patients with congestive heart failure / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 351-353, 2003.
Article in Chinese | WPRIM | ID: wpr-304164
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Astragalus Injection (AI) on the humoral immunity (IgG, IgA and IgM), cellular immunity (T-lymphocyte subsets) and soluble interleukin-2 receptor (sIL-2R) in patients with congestive heart failure (CHF).</p><p><b>METHODS</b>Sixty-two in-patients with CHF, whose heart function belonged to NYHA grade II-IV, were randomly divided into two groups. The treated group was treated with AI 30 ml (equivalent to 60 g crude drug), and the control group was treated by nitroglycerine injection 10 mg, the drugs were administered respectively by adding in 5% glucose solution 500 ml for intravenous dripping, once a day, 20 days as one therapeutic course. Venous blood from cubital vein was collected before and after treatment to detect the IgG, IgA, IgM, T-lymphocyte subsets and sIL-2R, and the clinical effect of treatment was evaluated.</p><p><b>RESULTS</b>The clinical heart function markedly improved rate and total effective rate in the treated group was 25.8% and 74.2% respectively, significantly better than those in the control group respectively (P < 0.05 or P < 0.01), the left ventricular ejecting fraction (LVEF) and end syctolic volume (ESV) were improved in both groups (P < 0.05, P < 0.01), and the improvement in the treated group was superior to that in the control group (P < 0.05). In the treated group after treatment, the CD4 level and CD4/CD8 ratio increased (P < 0.05), levels of sIL-2R, IgG and IgA lowered (P < 0.05) significantly, while those in the control group were not changed significantly (P > 0.05).</p><p><b>CONCLUSION</b>AI could improve the immune function of CHF patients, and can be taken as an important auxiliary treatment for CHF.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Infusions, Intravenous / Immunoglobulin G / Drugs, Chinese Herbal / Receptors, Interleukin-2 / Adjuvants, Immunologic / T-Lymphocyte Subsets / Coronary Disease / Astragalus Plant / Therapeutic Uses Limits: Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Infusions, Intravenous / Immunoglobulin G / Drugs, Chinese Herbal / Receptors, Interleukin-2 / Adjuvants, Immunologic / T-Lymphocyte Subsets / Coronary Disease / Astragalus Plant / Therapeutic Uses Limits: Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2003 Type: Article