Effect of congsheng capsule on intracellular calcium concentration in mice after ischemic cerebral injury / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 281-283, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-304184
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Congsheng Capsule (CSC) in intracellular Ca2+ concentration in cerebral intra-synaptosomes of ischemia/reperfusion mice and analogous ischemic injured neurons to estimate the mechanism of CSC in antagonizing ischemic cerebral injury.</p><p><b>METHODS</b>The concentration of Ca2+ in cerebral intra-synaptosomes of mice and in neurocyte suspension of fetal mice were determined using Fura-2/AM double wavelength fluorescence spectrophotometer.</p><p><b>RESULTS</b>CSC 3 g/kg and 9 g/kg through gastrogavage could relieve the degree of calcium overloading of intra-synaptosomes in mice after cerebral ischemia/reperfusion. The CSC containing serum could inhibit the elevation of Ca2+ content in neurocytes induced by 1 hour hypoxia and glutamate of high concentration (200 mumol/L).</p><p><b>CONCLUSION</b>CSC plays a role in antagonizing ischemic injury through relieving the calcium overloading after cerebral ischemia.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Synaptosomes
/
Brain
/
Capsules
/
Drugs, Chinese Herbal
/
Calcium Channel Blockers
/
Reperfusion Injury
/
Brain Ischemia
/
Calcium
/
Rats, Wistar
/
Neuroprotective Agents
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2003
Type:
Article
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