Effect of lugu Ganoderma lucidum on low-density lipoprotein oxidation and monocyte adhesion to endothelium / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 534-537, 2002.
Article
in Zh
| WPRIM
| ID: wpr-304205
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Lugu Ganoderma Lucidum (LGL) on low-density lipoprotein (LDL) oxidation and monocyte adhesion to endothelium (AdM-E) induced by oxydative LDL and advanced glycosylation endproducts (AGE) by using serum pharmacological technique.</p><p><b>METHODS</b>LDL oxidation was determined by measuring the thiobarbituric acid reactive substances in the supernatants, and AdM-E was determined by measuring myeloperoxidase activity of adherent monocyte.</p><p><b>RESULTS</b>Serum derived from rats 0.5 hrs, 1 hr, 2 hrs, 3 hrs after LGL administering 0.12 g/kg once and 0.5 hrs, 1 hr after LGL administering twice showed no significant effect on LDL oxidation, but the serum from rats 2 hrs, 3 hrs after LGL 0.12 g/kg administering twice or from rats after 10 successive days LGL administering in dose of 0.12 g/kg, 0.24 g/kg and 0.72 g/kg, all could lower the LDL oxidation (P < 0.05). Besides, the serum from rats with 10 days LGL administering of all dosages also could inhibit AdM-E induced by AGE (P < 0.05), and those of 0.24 g/kg and 0.72 g/kg could inhibit AdM-E induced by oxydative LDL (P < 0.05).</p><p><b>CONCLUSION</b>LGL could decrease LDL oxidation and AdM-E induced by AGE or oxydative LDL.</p>
Full text:
1
Index:
WPRIM
Main subject:
Oxidation-Reduction
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Pharmacology
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Umbilical Veins
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Drugs, Chinese Herbal
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Endothelium, Vascular
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Monocytes
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Random Allocation
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Cell Adhesion
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Cells, Cultured
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Rats, Sprague-Dawley
Type of study:
Clinical_trials
Limits:
Animals
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2002
Type:
Article