Study on induction of ginsenosides on HL-60 cell apoptosis / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 450-452, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-304230
ABSTRACT
<p><b>OBJECTIVE</b>To observe whether the Ginsenosides (GS) could induce HL-60 cell line apoptosis from promyelocytic leukemia.</p><p><b>METHODS</b>HL-60 cells were treated with GS of various concentration to observe the effect of GS on cell morphological change, the DNA content change by flow cytometry, DNA ladder by electrophoresis, and apoptosis rate by Annexin V-FITC test of the cells.</p><p><b>RESULTS</b>GS could inhibit the growth of HL-60 cells and induce cell apoptosis in a certain scope of dose and reacting time.</p><p><b>CONCLUSION</b>GS could specifically induce apoptosis in HL-60 cells, which provides an experimental basis for treatment of leukemia with GS as an supplemntary agent of chemotherapy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
DNA, Neoplasm
/
Cell Division
/
Apoptosis
/
HL-60 Cells
/
Ginsenosides
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2002
Type:
Article
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