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Effect of Panax notoginseng saponins on human kidney fibroblast / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 47-49, 2002.
Article in Chinese | WPRIM | ID: wpr-304251
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Panax notoginseng saponins (PNS) on cell proliferation, type I collagen secretion and integrin beta 1 expression in human kidney fibroblast (KFB).</p><p><b>METHODS</b>KFB were cultured and stimulated by PNS in vitro. The cell proliferation, type I collagen secretion and integrin beta 1 expression in KFB were measured by methyl thiazolyl tetrazolium (MTT), enzyme-linked immunoabsorbent assay (ELISA) and flowcytometry respectively.</p><p><b>RESULTS</b>Within its optimal concentration range and effective time range, PNS could obviously inhibit the proliferation, type I collagen secretion and integrin beta 1 expression (all P < 0.05) in human KFB.</p><p><b>CONCLUSION</b>PNS would possibly be an effective drug for renal interstitial fibrosis prevention and treatment.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Saponins / Fibrosis / Cells, Cultured / Chemistry / Integrin beta1 / Cell Biology / Collagen Type I / Fibroblasts Limits: Humans Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Saponins / Fibrosis / Cells, Cultured / Chemistry / Integrin beta1 / Cell Biology / Collagen Type I / Fibroblasts Limits: Humans Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2002 Type: Article