Effect of Panax notoginseng saponins on human kidney fibroblast / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 47-49, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-304251
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Panax notoginseng saponins (PNS) on cell proliferation, type I collagen secretion and integrin beta 1 expression in human kidney fibroblast (KFB).</p><p><b>METHODS</b>KFB were cultured and stimulated by PNS in vitro. The cell proliferation, type I collagen secretion and integrin beta 1 expression in KFB were measured by methyl thiazolyl tetrazolium (MTT), enzyme-linked immunoabsorbent assay (ELISA) and flowcytometry respectively.</p><p><b>RESULTS</b>Within its optimal concentration range and effective time range, PNS could obviously inhibit the proliferation, type I collagen secretion and integrin beta 1 expression (all P < 0.05) in human KFB.</p><p><b>CONCLUSION</b>PNS would possibly be an effective drug for renal interstitial fibrosis prevention and treatment.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Saponins
/
Fibrosis
/
Cells, Cultured
/
Chemistry
/
Integrin beta1
/
Cell Biology
/
Collagen Type I
/
Fibroblasts
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2002
Type:
Article
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