Immune activity of heat shock protein gp96 and its application in active immunotherapy for tumor and infectious diseases / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 261-266, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-304495
ABSTRACT
Heat-shock protein gp96 associates with antigenic peptides derived from tumor and virus. Exogenous gp96-peptide complexes are taken up by antigen-presenting cells through interaction with its receptor CD91 on the cell surface, and cross-present antigenic peptides to MHC class I molecules by a peptide relay line in the endoplasmic reticulum for specific T-cell activation. Meanwhile, gp96 has been shown to initiate innate immune responses through interaction with toll-like receptor 2 and toll-like receptor 4. Recent studies have shown a gp96-mediated immune balance between CTL and Tregs. With the further understanding of counteracting immunosuppressive mechanisms in gp96-induced cellular immune responses, and establishment of high level production of recombinant gp96 by the yeast, gp96 appears to be a promising candidate for designing effective therapeutic vaccines against tumor and infectious diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Communicable Diseases
/
Immunotherapy, Active
/
T-Lymphocytes, Regulatory
/
Therapeutic Uses
/
Allergy and Immunology
/
Heat-Shock Proteins
/
Methods
/
Neoplasms
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2012
Type:
Article
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