Plant-specific type III polyketide synthases superfamily: crystal structures and functions / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1-14, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-304518
ABSTRACT
Plant type III polyketide synthase (PKS) generates backbones of a variety of plant secondary metabolites with diverse functions, and has long been models to elucidate the relationship between the three-dimensional structure and function. More than 80 type IIII PKS crystal structures with different functions have been reported in Protein Data Bank, including the crystal structures of the well-studied Chalcone Synthase of plant type III PKS, as well as the 6 other kinds of PKSs in the family, which are critical for understanding the structural basis for diverse starter molecule selectivity, polyketide chain length and the cyclization reaction. Structure-based analysis and site-directed mutagenesis are foundation for the investigation of enzyme engineering, genetic and metabolic engineering. This review summarized 7 plant-specific type III PKS in the aspects of their crystal structures and functions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Plant Proteins
/
Plants
/
Substrate Specificity
/
Acyltransferases
/
Molecular Sequence Data
/
Catalysis
/
Genetic Engineering
/
Chemistry
/
Amino Acid Sequence
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2012
Type:
Article
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