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Kangle Decoction for erectile dysfunction with liver-qi stagnation and kidney deficiency / 中华男科学杂志
National Journal of Andrology ; (12): 538-542, 2016.
Article in Chinese | WPRIM | ID: wpr-304703
ABSTRACT
<p><b>Objective</b>To observe the clinical efficacy of Kangle Decoction in the treatment of erectile dysfunction (ED) with liver-qi stagnation and kidney deficiency.</p><p><b>METHODS</b>A total of 79 ED patients with liver-qi stagnation and kidney deficiency were randomly assigned to an experimental group (aged [36.62±8.05] yr and with a disease course of [18.15±6.41] mo) and a control group (aged [37.44±8.10] yr and with a disease course of [17.51±6.79] mo), the former treated orally with Kangle Decoction at 0.5 dose bid while the latter with Cialis at 10 mg qd alt, both for 8 weeks. Before treatment, after 4 and 8 weeks of medication, and at 4 weeks after drug withdrawal, we obtained the scores of the patients in the International Index of Erectile Function-5 (IIEF-5), Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS), and Short-Form Psychological and Interpersonal Relationship Scales (SF-PAIRS), and compared the indexes between the two groups of patients.</p><p><b>RESULTS</b>The IIEF-5 score was dramatically increased in both the treatment and control groups after 4 weeks (13.40±2.42 and 16.00±2.68) and 8 weeks of medication (18.60±3.50 and 18.59±3.80) and at 4 weeks after drug withdrawal (17.00±3.05 and 13.95±2.61) as compared with the baseline (10.78±2.28 and 10.77±2.33) (P<0.05 ), even higher in the treatment than in the control group after drug withdrawal (P<0.05 ). The EDITS scores in the treatment and control groups were (28.88±3.31 and 28.90±3.31) after 4 weeks of intervention, (29.68±3.30 and 29.13±3.32) after 8 weeks of intervention, and (29.20±2.92 and 26.82±3.23) at 4 weeks after drug withdrawal, all significantly higher in the former than in the latter group after drug withdrawal (P<0.05 ). The sexual self-confidence score (SSCS), sexual spontaneity score (SSS), and sexual time-concern score (STCS) were all improved in the treatment and control groups after medication as compared with the baseline (P<0.05 ), even higher in the former than in the latter group after drug withdrawal (P<0.05 ).</p><p><b>CONCLUSIONS</b>Kangle Decoction has a definite efficacy in the treatment of ED with liver-qi stagnation and kidney deficiency, with few adverse reactions and long-term post-withdrawal effect, and therefore deserves a wide clinical application.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Self Concept / Sexual Behavior / Drugs, Chinese Herbal / Treatment Outcome / Patient Satisfaction / Qi / Therapeutic Uses / Drug Therapy / Tadalafil / Erectile Dysfunction Limits: Adult / Humans / Male Language: Chinese Journal: National Journal of Andrology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Self Concept / Sexual Behavior / Drugs, Chinese Herbal / Treatment Outcome / Patient Satisfaction / Qi / Therapeutic Uses / Drug Therapy / Tadalafil / Erectile Dysfunction Limits: Adult / Humans / Male Language: Chinese Journal: National Journal of Andrology Year: 2016 Type: Article