Sperm acrosome formation-associated genes in mice: Advances in studies / 中华男科学杂志
National Journal of Andrology
;
(12): 72-76, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-304746
ABSTRACT
Spermiogenesis is a complex process of differentiation and morphologic alteration, in which sperm acrosome formation is an important stage. Acrosome is an essential component of the sperm head, which develops in four distinct phases Golgi, cap, acro- somal, and maturation, each supported by precise and orderly regulation of various genes. The regulatory genes which act on Golgi ap- paratus include GOPC, Hrb, SPATA16, PICK1, and CK2α', those involved in the cap phase are Fads2, syntaxin 2, Kdm3a, and UBR7, and participating in acrosomal and maturation phases are KIFC1, Rnf19a, and DPY19L2. The abnormalities of these genes may affect male fertility by influencing the connection of the nuclear dense lamina and acroplaxome with the nuclear membrane and then the fusion and transportation of vesicles. This review focuses on the genes involved in different phases of acrosome formation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Sperm Head
/
Spermatids
/
Spermatogenesis
/
Spermatozoa
/
Acrosome
/
Genetics
/
Golgi Apparatus
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2016
Type:
Article
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