Ouabain and asthenospermia / 中华男科学杂志
National Journal of Andrology
;
(12): 1129-1133, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-304761
ABSTRACT
Asthenospermia accounts for about 30% of the causes of male infertility. Currently, most drugs for asthenospermia lack specificity and desirable therapeutic efficiency. An insight into the pathogenesis of asthenospermia is important for the development of specific therapies for this disease. The protein Na+/K(+)- ATPase α4 isoform (NKA4) presents in both mature testis tissue and the sperm tail, the absence or reduced activity of which may significantly decrease sperm motility. Ouabain is a natural inhibitor of NKA4, suppressing its activity by specifically binding the ouabain site in it. The hypothalamus and adrenal cortex excrete an ouabain-like steroid hormone called endogenous ouabain (EO), which may be associated with the pathogenesis of asthenospermia by inhibiting the activity of NKA4, affecting Na+/H+ exchange, Na+/Ca2+ exchange and sperm cell membrane potential, and eventually reducing sperm motility.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ouabain
/
Sperm Motility
/
Sperm Tail
/
Spermatozoa
/
Testis
/
Chemistry
/
Sodium-Potassium-Exchanging ATPase
/
Protein Isoforms
/
Asthenozoospermia
/
Membrane Potentials
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2015
Type:
Article
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