Your browser doesn't support javascript.
loading
Preliminary investigation on polymorphs of two traditional Chinese medicine reference substances / 中国中药杂志
Article in Chinese | WPRIM | ID: wpr-304824
Responsible library: WPRO
ABSTRACT
Crystal structures of chemical drugs has been being investigated widely. But few attention has been paid to polymorphs-phenomena of active ingredients from Traditional Chinese Medicine(TCM). Taking anhydrous dehydroandrographolide and hydrousprim-O-glucosylcimifugin as example, differences between TCM reference substances (RSs) with different crystal structures were discussed by using microscopy, melting point determination, differential thermal analysis (DTA) and infrared (IR) methods. The results showed that different crystal structures could lead to change of melting points, thermal behaviors and IR spectrum. It's indicated that polymorphs may be considered if different physicochemical properties were obtained when applying TCM RS. Differences of chemical properties of active ingredients from TCM with different crystal structures need further investigation.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Reference Standards / Spectrophotometry, Infrared / Drugs, Chinese Herbal / Molecular Structure / Chemistry / Crystallization / Transition Temperature / Differential Thermal Analysis / Medicine, Chinese Traditional / Methods Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2015 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Reference Standards / Spectrophotometry, Infrared / Drugs, Chinese Herbal / Molecular Structure / Chemistry / Crystallization / Transition Temperature / Differential Thermal Analysis / Medicine, Chinese Traditional / Methods Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2015 Type: Article