The clinical features and outcomes of immunoglobulin light-chain amyloidosis with heart involvement / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 340-343, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-304908
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the clinical features and outcomes of patients with immunoglobulin light-chain amyloidosis (AL) who had heart involvement.</p><p><b>METHODS</b>Clinical features and outcomes of AL amyloidosis patients with heart involvement in the past 7 years in our hospital were retrospectively analyzed.</p><p><b>RESULTS</b>Cardiac involvement was seen in 36 out of the 60 AL patients (60%). The clinical manifestations of cardiac amyloidosis included heart failure (50%), low QRS voltage (47.2%) and pseudomyocardial infarction (33.3%) in electrocardiography, as well as thickening of ventricular wall (63.9%), echo of granular sparkling texture (11.1%), atria dilation (33.3%) and diastolic dysfunction (30.6%) in echocardiography. The prognosis was poor, with a median survival time of 13.9 months.</p><p><b>CONCLUSION</b>Patients of AL amyloidosis with cardiac involvement are not rare. Thickening of ventricular wall and diastolic dysfunction are the most common characteristics. Special attention should be paid to this disease.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Retrospective Studies
/
Immunoglobulin Light Chains
/
Diagnosis
/
Amyloidosis
/
Cardiomyopathies
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2007
Type:
Article
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