Association between uroguanylin G-247A polymorphism and blood pressure/fluid and electrolytes homeostasis / 中华心血管病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the association between uroguanylin G-247A polymorphism and blood pressure/fluid and electrolytes homeostasis.</p><p><b>METHODS</b>Uroguanylin genotype was determined by restrictive fragment length polymorphism (RFLP) and blood pressure as well as fluid and electrolytes homeostasis were measured in 442 volunteers from Jing Ning County, ZheJiang Province. Data were analyzed by ANOVA, Generalized Estimating Equations (GEE), and Quantitative Transmission Disequilibrium Test (QTDT).</p><p><b>RESULTS</b>Ten uroguanylin gene polymorphisms were detected in 40 subjects by direct sequencing, all were reported in the NCBI SNP database. We selected the G-247A polymorphism for genotyping. Compared with G allele carriers, AA homozygotes had a higher urinary volume (P = 0.08), higher excretions of sodium (P = 0.07) and potassium (P < 0.001), but similar systolic and diastolic blood pressure (P > 0.32) both before and after adjustment for sex, age, body-mass index, current smoking, alcohol intake, and antihypertensive treatment.</p><p><b>CONCLUSIONS</b>The uroguanylin G-247A polymorphism was associated with urinary volume and sodium and potassium excretions.</p>