Subtype and sequence analysis of the gag genes for HIV-1 strains isolated in Hubei province / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 460-463, 2012.
Article
in Zh
| WPRIM
| ID: wpr-305009
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the characteristic of subtypes and genetic diversity of HIV-1 circulating in Hubei province and its molecular epidemiological linkages with regard to risk factors of viral transmission.</p><p><b>METHODS</b>plasma samples of 80 diagnosed individuals was characterized. The gene fragments of gag were amplified by reverse transcriptase polymerase chain reaction (RT-PCR) and HIV-1 genotypes were determined based on the nucleotide sequences of gag region.</p><p><b>RESULTS</b>Seven HIV-1 group M subtypes or CRF including B, B', G, CRF01-AE, CRF07-BC, CRF08-BC and CRF15-01B were identified. CRF01-AE was found to be the most dominant subtype (48.4%) followed by CRF7-BC (22.6%) and B' (12.9%).</p><p><b>CONCLUSION</b>The data from this study indicate the existence of multiple HIV-1 subtypes or CRFs in Hubei province and the surveillance of HIV-1 gene variation should be paid more attention to.</p>
Full text:
1
Index:
WPRIM
Main subject:
Phylogeny
/
Virology
/
HIV Infections
/
China
/
Epidemiology
/
HIV-1
/
Classification
/
Gag Gene Products, Human Immunodeficiency Virus
/
Genetics
/
Genotype
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2012
Type:
Article