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Expression and significance of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 279-281, 2012.
Article in Chinese | WPRIM | ID: wpr-305059
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue and relationship with progression of breast carcinoma.</p><p><b>METHODS</b>92 cases of breast carcinoma tissue and homologous paraneoplastic breast tissue were selected, expressive level of HER-2/neu mRNA and RECK mRNA were detected with RT-PCR, expressive difference of HER-2/neu mRNA and RECK mRNA were contrasted between breast carcinoma tissue and homologous paraneoplastic breast tissue, along with different TNM stage breast carcinoma tissue and differentiate breast carcinoma.</p><p><b>RESULTS</b>The level of HER-2/neu mRNA was higher and RECK mRNA was lower in breast carcinoma tissue than homologous paraneoplastic breast tissue, the expressive level of HER-2/neu mRNA and RECK mRNA was remarkably different along with different TNM stage breast carcinoma tissue and differentiate breast carcinoma, there was a negative correlation between expressive level of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue.</p><p><b>CONCLUSIONS</b>Expression of HER-2/neu mRNA and RECK mRNA was abnormal in breast carcinoma tissue, HER-2/neu mRNA and RECK mRNA regulate each other and mutual participate occurrence and progression of breast carcinoma.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Breast Neoplasms / RNA, Messenger / Carcinoma / Gene Expression Regulation, Neoplastic / Receptor, ErbB-2 / GPI-Linked Proteins / Genetics / Metabolism Limits: Adult / Aged / Female / Humans Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Breast Neoplasms / RNA, Messenger / Carcinoma / Gene Expression Regulation, Neoplastic / Receptor, ErbB-2 / GPI-Linked Proteins / Genetics / Metabolism Limits: Adult / Aged / Female / Humans Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2012 Type: Article