Expression and significance of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 279-281, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-305059
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue and relationship with progression of breast carcinoma.</p><p><b>METHODS</b>92 cases of breast carcinoma tissue and homologous paraneoplastic breast tissue were selected, expressive level of HER-2/neu mRNA and RECK mRNA were detected with RT-PCR, expressive difference of HER-2/neu mRNA and RECK mRNA were contrasted between breast carcinoma tissue and homologous paraneoplastic breast tissue, along with different TNM stage breast carcinoma tissue and differentiate breast carcinoma.</p><p><b>RESULTS</b>The level of HER-2/neu mRNA was higher and RECK mRNA was lower in breast carcinoma tissue than homologous paraneoplastic breast tissue, the expressive level of HER-2/neu mRNA and RECK mRNA was remarkably different along with different TNM stage breast carcinoma tissue and differentiate breast carcinoma, there was a negative correlation between expressive level of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue.</p><p><b>CONCLUSIONS</b>Expression of HER-2/neu mRNA and RECK mRNA was abnormal in breast carcinoma tissue, HER-2/neu mRNA and RECK mRNA regulate each other and mutual participate occurrence and progression of breast carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Breast Neoplasms
/
RNA, Messenger
/
Carcinoma
/
Gene Expression Regulation, Neoplastic
/
Receptor, ErbB-2
/
GPI-Linked Proteins
/
Genetics
/
Metabolism
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2012
Type:
Article
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