HBV genotypes distribution and YMDD spontaneous mutation in Qingdao population / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 250-252, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-305068
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution of hepatitis B virus (HBV) genotypes in Qingdao, and the relationship of HBV genotypes with the serum HBV-DNA levels and HBV YMDD spontaneous mutation of patients, then to discuss the clinical significance.</p><p><b>METHODS</b>Hepatitis B virus genotypes and YMDD spontaneous mutation of 144 patients were detected by real time PCR (Taqman probe), then the results were analyzed by statistical method.</p><p><b>RESULTS</b>Of the 144 patients, 130 (90.3%) were genotype C, 12 (8.3%) were genotype B, and 2 (1.4%) were neither genotype B nor genotype C; 33 (22.9%) were detected to have YMDD mutation, and 25 (75.5%) were YVDD positive, 3 (9.1%) were YIDD positive, 5 (15.2%) were YVDD and YIDD positive. There were no significant differences between clinical diagnosis, serum HBV-DNA levels, YMDD spontaneous mutation and HBV genotypes (P > 0.05).</p><p><b>CONCLUSION</b>Genotype C is the dominant position for HBV genotype in Qingdao. Untreated patients with chronic hepatitis B have YMDD spontaneous mutation. HBV genotypes have no association with YMDD spontaneous mutation and the development of diseases.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Viral Proteins
/
Chemistry
/
China
/
Hepatitis B virus
/
Classification
/
DNA-Directed DNA Polymerase
/
Genetics
/
Genotype
/
Metabolism
/
Mutation
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2012
Type:
Article
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