Correlationship between chemokines and oxidative stress in chronic hepatitis B / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 246-249, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-305069
ABSTRACT
<p><b>OBJECTIVE</b>The aim of this study is to investigate the possible associations of chemokines IP-10, Rantes and oxidative stress in chronic hepatits B (CHB).</p><p><b>METHODS</b>70 CHB patients and 10 healthy controls were enrolled in the study. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of IFN-gamma-inducible protein-10 (IP-10) and regulated on activation normal T-cell-expressed and secreted (Rantes) and oxidative stress parameters (glutathione, GSH; glutathione disulfide, GSSG). Correlationship were analyzed by Spearman's rank correlation.</p><p><b>RESULT</b>The levels of IP-10 and Rantes were higher in CHB patients than healthy controls, and strong positive associations were found between IP-10/Rantes and alanine aminotransferase (ALT). The levels of GSH and GSH/GSSG were lower in CHB patients than healthy controls, and GSH and GSH/GSSG were negatively correlated with ALT. The levels of IP-10 and Rantes were negatively correlated with GSH and GSH/GSSG respectively.</p><p><b>CONCLUSION</b>Strong associations were found between chemokines and oxidative stress which participated in the pathogenesis of CHB.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Blood
/
Hepatitis B virus
/
Oxidative Stress
/
Chemokine CCL5
/
Hepatitis B, Chronic
/
Glutathione Disulfide
/
Alanine Transaminase
/
Chemokine CXCL10
/
Genetics
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2012
Type:
Article
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