Advance in studies on regulatory mechanism of phenotype polarization of macrophages and intervention with traditional Chinese medicines / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 180-184, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-305326
ABSTRACT
Macrophages are heterogeneous and diversified, and can be polarized into different phenotypes in various microenvironments and physiological or pathological conditions. Major macrophage subpopulations including classically activated(M1) and alternatively activated(M2) macrophages, which represent different surface receptors, secret different cytokines and chemokines, are regulated by different signal paths of transcriptions and epigenetic levels, and play distinctive roles in tumor progress. TCMs may improve the microenvironment by regulating phenotype polarization of macrophages. So far, specific biomarkers and polarized molecules mechanisms generated through the macrophage polarization approach are still unclear. In this article, we merely summarize the advance in domestic and foreign studies on phenotype polarization of macrophages and regulatory mechanisms and look into the future of intervention with TCMs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Physiology
/
Cell Polarity
/
Drug Therapy
/
Allergy and Immunology
/
Macrophages
/
Medicine, Chinese Traditional
/
Neoplasms
Type of study:
Diagnostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2015
Type:
Article
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