Effects of anticoagulation protein defect in maternal plasma on spontaneous abortion / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 290-292, 2004.
Article
in English
| WPRIM
| ID: wpr-305479
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mechanism of anticoagulation protein defect in the pathogenesis of unexplained recurrent miscarriage.</p><p><b>METHODS</b>Fifty-seven patients with a history of unexplained abortion were enrolled as the investigation group for tests of protein C, protein S, antithrombin III (AT-III), as well as activated protein C resistance (APC-R). The control group consisted of fifty healthy women with a history of normal pregnancy and delivery. Blood samples were obtained for, measuring serum activity of protein C, protein S, AT-III, and APC-R. Patients with positive APC-R were tested for factor V (FV) Leiden gene mutation by PCR-RFLP method.</p><p><b>RESULTS</b>Of the 57 patients, 12 (21.1%), 1 (1.8%), and 5 (8.8%) cases were found with protein S, protein C, and AT-III deficiency respectively, and 13 (22.8%) cases with positive results of APC-R. Of the control group, no protein C or AT-III deficiency was ever found, whereas 2 (4.0%) volunteers were presented with protein S deficiency and 3 (6.0%) with positive results of APC-R. No FV Leiden gene mutation was identified in all the patients with positive APC-R results. Late spontaneous abortion cases had higher incidence of anticoagulation protein defect than the early cases.</p><p><b>CONCLUSION</b>Anticoagulation protein defect may play a role in the pathogenesis of fetal loss, especially for those occurring in late stage of pregnancy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Factor V
/
Protein C
/
Antithrombin III
/
Abortion, Habitual
/
Protein S
/
Point Mutation
/
Protein S Deficiency
/
Antithrombin III Deficiency
/
Activated Protein C Resistance
Type of study:
Prognostic study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Chinese Medical Sciences Journal
Year:
2004
Type:
Article
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