Experimental studies on treatment of HSV infections with photodynamic therapy using 5-aminolevulinic acid / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 79-82, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-305488
ABSTRACT
<p><b>OBJECTIVE</b>To investigate in vitro and in vivo anti-human herpes simplex virus effects of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA).</p><p><b>METHODS</b>Guinea pigs model of cutaneous herpes virus infection was applied, and Vero cells infected by HSV-I and HSV-II were used as experimental systems to observe the antiherpes effect of ALA-PDT.</p><p><b>RESULTS</b>The in vitro experiments showed that ALA-PDT has antiherpes effect on HSV-I and HSV-II, its effect was similar to that of acyclovir. The results of animal experiments showed that ALA-PDT had significant therapeutic effect on guinea pigs model of cutaneous herpes virus infection, the effect was dose-related.</p><p><b>CONCLUSION</b>ALA-PDT could be effective in treating HSV infections, which may provide a new approach to the treatment of viral infections.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Photochemotherapy
/
Virology
/
Vero Cells
/
Random Allocation
/
Chlorocebus aethiops
/
Treatment Outcome
/
Skin Diseases, Viral
/
Simplexvirus
/
Therapeutic Uses
/
Disease Models, Animal
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2007
Type:
Article
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