Subject diagnostic value of detecting a1pha-fetoprotein variants with a new microspincolumn method in hepatocellular carcinoma / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 67-69, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-305492
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the usefulness of new microspincolumn method for the measurement of a1pha-fetoprotein variant AFP-L3 in differentiation of benign and malignant liver disease and the warming for liver cancer.</p><p><b>METHODS</b>AFP-L3 was isolated by using microspincolumn coupled with lens culinaris agglutinin (LCA), AFP and AFP-L3 were determined with chemiluminescent immunoassay, the proportion of AFP-L3 levels AFP-L3(%) were calculated, and the relationship between the elevated AFP-L3(%) levels and benign and malignant liver disease was analyzed.</p><p><b>RESULTS</b>The levels of AFP-L3(%) in serum of patients with hepatocellular carcinoma was significantly higher than those in the patients with other liver diseases (P < 0.001). Taking AFP-L3(%) >or= 10% as the diagnostic criteria, the sensitivity for diagnosis of liver cancer was 90.9%.</p><p><b>CONCLUSION</b>Detection of AFP-L3 seemed to be of clinical value in diagnosis and differential diagnosis of hepatocellular carcinoma; it may be especially important for identifying patients with hepatocellular carcinoma whose a1pha-fetoprotein level is low.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Immunoassay
/
Alpha-Fetoproteins
/
Sensitivity and Specificity
/
Carcinoma, Hepatocellular
/
Diagnosis
/
Diagnosis, Differential
/
Hepatitis, Chronic
/
Liver Cirrhosis
/
Liver Neoplasms
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2007
Type:
Article
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