Comparison of different combination therapies for children with HBeAg positive chronic hepatitis B / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 62-63, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-305494
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the advantages of combination therapy with interferon-alpha plus nucleoside analogue-lamivudine or HBV vaccine in children with HBeAg positive chronic hepatitis B.</p><p><b>METHODS</b>A total of 120 patients with HBeAg positive chronic hepatitis B were divided into three groups, 40 patients per group. Each group was treated with one of the following therapies respectively Group A IFN-alpha 1b 10 MU/m2 three times per week (Tiw); Group B IFN-alpha 1b 10MU/m2 three times per week (Tiw) plus lamivudine 3 mg/kg for 6 months. Group C IFN-alpha 1b 10 MU/m2 three times per week (Tiw) plus HBV vaccine 30 microg one a month.</p><p><b>RESULTS</b>There was no significant difference in normalizing rate of ALT among the three groups at end of treatment. There was more significant difference in negative rate (seroconversion) of serum HBV DNA and HBeAg in group B than group A and group C (P less than 0.05).</p><p><b>CONCLUSION</b>The combination therapy of IFN-alpha 1b plus lamivudine seemed to be more effective than the therapy with IFN-alpha alone and the combination of IFN-alpha and HBV vaccine.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
DNA, Viral
/
Hepatitis B virus
/
Follow-Up Studies
/
Treatment Outcome
/
Interferon-alpha
/
Hepatitis B Vaccines
/
Lamivudine
/
Anti-HIV Agents
/
Hepatitis B, Chronic
Type of study:
Observational study
/
Prognostic study
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2007
Type:
Article
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