A clinical study on combined serum hepatic fibrosis-related markers and ultrasound parameters to diagnose hepatic fibrosis / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 56-58, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-305496
ABSTRACT
<p><b>OBJECTIVE</b>This study attempted to explore the value of combining serum hepatic fibrosis-related markers and ultrasound parameters together on diagnosis of hepatic fibrosis.</p><p><b>METHODS</b>Six serum markers and 8 ultrasound parameters were measured from 100 patients with chronic hepatitis B or cirrhosis. The results of the serum hepatic fibrosis-related markers and ultrasound in disease group were analyzed and compared with the findings of hepatic pathology.</p><p><b>RESULTS</b>By filtrating,the group of platelet derived growth factor-BB (PDGF-BB) plus hyaluronic acid (HA) plus echo characteristics of liver parenchyma (LPEC) plus length of spleen (SL) had the highest Se and Spe, which were 90.7% and 85.4% respectively.</p><p><b>CONCLUSION</b>The advantageous combination of serum markers and ultrasound parameters can significantly improve Se and Spe, which is superior to any single serum index or ultrasound parameter. And it was a better non-invasive method for diagnosing hepatic fibrosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Platelet-Derived Growth Factor
/
Diagnostic Imaging
/
Biomarkers
/
Reproducibility of Results
/
Transforming Growth Factor beta
/
Sensitivity and Specificity
/
Ultrasonography, Doppler, Color
/
Hepatitis B, Chronic
/
Tissue Inhibitor of Metalloproteinase-1
Type of study:
Diagnostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS