Significance of nerve growth factor expression in the prostate tissue of spontaneously hypertensive rats / 中华男科学杂志
National Journal of Andrology
;
(12): 781-784, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-305791
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes of the expressions of the nerve growth factor (NGF) and its mRNA in the prostate tissues of spontaneously hypertensive rats (SHR) of different ages and their significance.</p><p><b>METHODS</b>SHRs and normotensive Wistar Kyoto (WKY) rats were killed at 1 month (young), 6 months (adult) and 12 months (aging), respectively, 5 in each group. Their prostate indexes were calculated, and the expressions of NGF and its mRNA in the ventral prostate tissue were detected by immunohistochemistry and RT-PCR.</p><p><b>RESULTS</b>The prostate indexes of the SHR and WKY groups were 1.16 +/- 0.06 and 1.03 +/- 0.09 at 1 month, 1.12 +/- 0.14 and 0.93 +/- 0.07 at 6 months, and 1.11 +/- 0.05 and 0.96 +/- 0.09 at 12 months, significantly higher in the former group than in the latter either at 6 or at 12 months (P < 0.05), but with no obvious difference at 1 month (P > 0.05). The expressions of NGF and its mRNA in the ventral prostate tissue were detected in all groups, and elevated gradually with the increase of age (P < 0.05). Among those of the same age, the expression levels were markedly higher in the SHR than in the WKY group (P < 0.05).</p><p><b>CONCLUSION</b>In SHRs with benign prostate hyperplasia (BPH), the enhanced excitation of the sympathetic nervous system may be a common mechanism underlying BPH and hypertension, and NGF plays an important role in it.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostate
/
Prostatic Hyperplasia
/
Rats, Inbred SHR
/
Rats, Inbred WKY
/
Aging
/
Metabolism
/
Nerve Growth Factors
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2011
Type:
Article
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