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Association of IL-6-572C > G polymorphism with the susceptibility to prostate cancer in the Chinese Han population in Jiangsu and Anhui area / 中华男科学杂志
National Journal of Andrology ; (12): 707-711, 2011.
Article in Chinese | WPRIM | ID: wpr-305802
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of the IL-6 -572C > G polymorphism with the risk of prostate cancer (PCa) in the Chinese Han population in Jiangsu and Anhui area.</p><p><b>METHODS</b>We obtained peripheral blood genome DNA from 200 PCa patients and 279 age-matched PCa-free healthy controls, analyzed the site polymorphism of IL-6 -572C > G with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique, and studied the correlation of different genotypes with the susceptibility to PCa.</p><p><b>RESULTS</b>The subjects that carried the CCGG genotype had a risk of PCa 2.46 times that of the CC genotype carriers (95% CI = 1.41-4.29), and 2.47 times that of the CC/GC genotype carriers (95% CI = 1.47-4.17). This risk was significantly increased among the following subgroups of CCGG genotype carriers age > 70 yr (OR = 3.06, 95% CI 1.44-6.49), BMI > 23 kg/m2 (OR = 3.72, 95% CI 1.79-7.74), no cigarette smoking (OR = 2.96, 95% CI 1.30-6.72), alcohol drinking (OR = 2.73, 95% CI 1.28-5.79), with a family history of cancer (OR = 6.67, 95% CI 1.50-29.69).</p><p><b>CONCLUSION</b>In the Chinese Han population in Jiangsu and Anhui area, IL-6 -572C > G polymorphism is associated with the susceptibility to PCa, and GG might be a susceptible genotype to PCa.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prostatic Neoplasms / Case-Control Studies / China / Epidemiology / Interleukin-6 / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Asian People / Gene Frequency / Genetics Type of study: Observational study / Risk factors Limits: Aged / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: National Journal of Andrology Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prostatic Neoplasms / Case-Control Studies / China / Epidemiology / Interleukin-6 / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Asian People / Gene Frequency / Genetics Type of study: Observational study / Risk factors Limits: Aged / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: National Journal of Andrology Year: 2011 Type: Article