Regulatory effect of GDNF on the proliferation and differentiation of mammalian spermatogonial stem cells / 中华男科学杂志
National Journal of Andrology
;
(12): 628-633, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-305830
ABSTRACT
The glial cell-derived neurotrophic factor (GDNF) is a member of the transforming growth factor beta (Tgf-beta) superfamily, which is produced by Sertoli cells and plays an important role in the proliferation and differentiation of spermatogonial stem cells (SSC). The addition of proper amount of GDNF to the culture media can promote SSC proliferation in vitro. Besides, GDNF regulates the self-renewal and differentiation of SSCs through various signaling pathways. This review focuses on the effects of GDNF on the proliferation and differentiation of mammalian SSCs and GDNF-mediated signaling pathways.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spermatogonia
/
Stem Cells
/
Signal Transduction
/
Cell Differentiation
/
Cell Biology
/
Cell Proliferation
/
Glial Cell Line-Derived Neurotrophic Factor
/
Mammals
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2011
Type:
Article
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