Sperm DNA damage and unexplained recurrent spontaneous abortion / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the relationship of sperm DNA damage with unexplained recurrent spontaneous abortion (URSA).</p><p><b>METHODS</b>Sperm DNA fragmentation was evaluated by sperm chromatin dispersion (SCD), and the results were expressed in terms of DNA fragmentation index (DFI). DFIs were measured in the male partners of 56 women with URSA (the experiment group) and of 31 without URSA (the control group).</p><p><b>RESULTS</b>The DFI was shown to be (11.0% - 56.9%) in the experiment group, 21 (37.5%) of the subjects over 30%, as compared with (10.0% -36.8%) in the control group, only 8 (25.8%) of the subjects over 30%, significantly higher in the former than in the latter (29.4% vs 25.5%, P < 0.05).</p><p><b>CONCLUSION</b>There is a relationship between sperm DNA damage and URSA.</p>