Association of gr/gr deletion in the AZFc region of Y chromosome with male infertility: a meta-analysis / 中华男科学杂志
National Journal of Andrology
;
(12): 546-552, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-305846
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the association of gr/gr deletion in the AZFc region of Y chromosome with idiopathic male infertility using Meta-analysis.</p><p><b>METHODS</b>All relevant case-control studies addressing the relationship between gr/gr deletion and idiopathic male infertility were identified from PubMed, VIP and CNKI (from January 2003 to August 2010). Statistical analyses were performed with the RevMan4. 2 software.</p><p><b>RESULTS</b>Twenty eligible articles were selected in this study, including 5 246 cases of idiopathic infertility and 4 380 controls. The integrated data from the 20 studies revealed a significantly higher frequency of gr/gr deletion in the patients than in the controls, with an odds ratio (OR) of 1.63 (95% CI 1.23 -2.44) (P = 0.002). However, when the Meta-analysis was limited to 16 studies with stricter case and control selection criteria, the overall OR increased to 1.84 (95% CI 1.47 - 2.29) (P < 0.000 01). Thirteen studies showed that oligozoospermia patients had a significantly higher frequency of gr/gr deletion than controls (OR = 2.12, 95% CI 1.61 - 2.80) (P < 0.000 01). Eight studies showed a significant association between the gr/gr deletion subtype without DAZ1/DAZ2 gene copies and spermatogenic impairment (OR = 1.83, 95% CI 1.31 - 2.55) (P = 0.000 4), but no statistically significant differences were found in the frequency distribution of the gr/gr deletion subtype missing DAZ3/DAZ4 gene copies between the patients and controls (OR = 1.43, 95% CI 0.97 -2.11) (P = 0.07).</p><p><b>CONCLUSION</b>The present data suggest that gr/gr deletion may be one of the risk factors of male infertility.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Chromosome Deletion
/
Chromosomes, Human, Y
/
Genetics
/
Infertility, Male
Type of study:
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2011
Type:
Article
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