Effect of interleukin-8 in cell invasion and proliferation of human breast cancer / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1541-1544, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-306072
ABSTRACT
<p><b>OBJECTIVE</b>To identify the effect of interleukin-8 in cell progression and invasion of human breast cancer.</p><p><b>METHODS</b>Human cytokine antibody arrays were applied to screen a panel of cytokine expression from 11 human breast cancer cell lines, and the mechanism of identified key factors involved in breast cancer progression was studied.</p><p><b>RESULTS</b>Profiling of cytokine expression showed the expression of interleukin-8 was related to estrogen receptor status, metastasis and vimentin status in the 11 human breast cancer cell lines. Elevated expression of interleukin-8 in breast cancer cells had positive correlation with breast cancer invasion. Neutralization of antibody against interleukin-8 specifically blocked interleukin-8-mediated cell invasion. However, anti-interleukin-8 antibody did not influence the proliferation of breast cancer cells.</p><p><b>CONCLUSION</b>Interleukin-8 may be the key factor involved in human breast cancer progression and invasion, and play an important role in cell invasion of breast cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Breast Neoplasms
/
Enzyme-Linked Immunosorbent Assay
/
Immunohistochemistry
/
Tumor Cells, Cultured
/
Receptors, Estrogen
/
Interleukin-8
/
Tumor Suppressor Protein p53
/
Protein Array Analysis
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2005
Type:
Article
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