Polymorphism of metabolic gene and genetic susceptibility to prostate cancer / 中华外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the possible relationship between the single nucleotide polymorphism (SNP) of cytochrome P-450 CYP1A1 (CYP1A1) m1, m2 and GSTM1 [null] genotype and genetic susceptibility to prostate cancer (PC).</p><p><b>METHODS</b>Eighty-three PC patients and 115 age-matched healthy controls were enrolled in this study. All DNA samples from peripheral blood were genotyped for genetic polymorphisms of CYP1A1 and GSTM1 genes by genechip technique.</p><p><b>RESULTS</b>There was a significant difference in the frequency of GSTM1 [null] genotype in PC cases (57.8%) compared to healthy controls (41.7%) (chi(2) = 4.99, P = 0.025). Individuals with the GSTM1 [null] genotype demonstrated increased risk (OR = 1.9, 95% CI = 1.10-1.34). The frequency of the GSTM1 [null] genotype was also higher in patients with advanced stage or high grade disease. There were no significant differences in the frequent distribution of two locate of CYP1A1 polymorphisms between prostate cancer patients and healthy controls (P > 0.05).</p><p><b>CONCLUSIONS</b>GSTM1 [null] genotype may be linked to prostate cancer risk in Chinese population. GSTM1 [null] genotype was also related to the stage and grade, which may be helpful in determining the risk of locally disease and advanced PC.</p>