D8/17 Expression on B Lymphocytes of Children and Adolescents with Tic Disorder
Journal of the Korean Academy of Child and Adolescent Psychiatry
;
: 151-156, 2013.
Article
in Korean
| WPRIM
| ID: wpr-30609
ABSTRACT
OBJECTIVES:
It has been reported that higher percentage of B cells react with monoclonal D8/17 antibody in patients with rheumatic fever, childhood onset obsessive-compulsive disorder, Tourette's disorder, or prepubertal anorexia nervosa. The purpose of this study is to replicate the previous studies in a Korean young population with tic disorder and to identify any relationship between D8/17 and clinical symptoms.METHODS:
The binding of D8/17 to B cells was determined in patients with tic disorder (N=21) and healthy controls (N=9) by Fluorescence-Activated Cell Sorter analysis.RESULTS:
In the sample examined by this study, the average percentage of B cells expressing D8/17 in tic disorder was 2.05%; healthy controls was 3.15%. No statistically significant differences were found in the mean percentages of D8/17 between the two groups.CONCLUSION:
The expression of D8/17 in B cells was very low in this study. No subjects with tic disorder or healthy controls was above 12% in D8/17 positive proportion. Further studies, including higher number of patients and control group members, should be performed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rheumatic Fever
/
Tic Disorders
/
B-Lymphocytes
/
Anorexia Nervosa
/
Tourette Syndrome
/
Tics
/
Obsessive-Compulsive Disorder
Limits:
Adolescent
/
Child
/
Humans
Language:
Korean
Journal:
Journal of the Korean Academy of Child and Adolescent Psychiatry
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS