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D8/17 Expression on B Lymphocytes of Children and Adolescents with Tic Disorder
Journal of the Korean Academy of Child and Adolescent Psychiatry ; : 151-156, 2013.
Article in Korean | WPRIM | ID: wpr-30609
ABSTRACT

OBJECTIVES:

It has been reported that higher percentage of B cells react with monoclonal D8/17 antibody in patients with rheumatic fever, childhood onset obsessive-compulsive disorder, Tourette's disorder, or prepubertal anorexia nervosa. The purpose of this study is to replicate the previous studies in a Korean young population with tic disorder and to identify any relationship between D8/17 and clinical symptoms.

METHODS:

The binding of D8/17 to B cells was determined in patients with tic disorder (N=21) and healthy controls (N=9) by Fluorescence-Activated Cell Sorter analysis.

RESULTS:

In the sample examined by this study, the average percentage of B cells expressing D8/17 in tic disorder was 2.05%; healthy controls was 3.15%. No statistically significant differences were found in the mean percentages of D8/17 between the two groups.

CONCLUSION:

The expression of D8/17 in B cells was very low in this study. No subjects with tic disorder or healthy controls was above 12% in D8/17 positive proportion. Further studies, including higher number of patients and control group members, should be performed.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Rheumatic Fever / Tic Disorders / B-Lymphocytes / Anorexia Nervosa / Tourette Syndrome / Tics / Obsessive-Compulsive Disorder Limits: Adolescent / Child / Humans Language: Korean Journal: Journal of the Korean Academy of Child and Adolescent Psychiatry Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rheumatic Fever / Tic Disorders / B-Lymphocytes / Anorexia Nervosa / Tourette Syndrome / Tics / Obsessive-Compulsive Disorder Limits: Adolescent / Child / Humans Language: Korean Journal: Journal of the Korean Academy of Child and Adolescent Psychiatry Year: 2013 Type: Article