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Experience of diagnosis and treatment of carcinoma arising from congenital biliary duct cyst / 中华外科杂志
Chinese Journal of Surgery ; (12): 839-841, 2005.
Article in Chinese | WPRIM | ID: wpr-306201
ABSTRACT
<p><b>OBJECTIVE</b>To summarize the experience in diagnosis, prevention and treatment of carcinoma arising from congenital biliary duct cyst.</p><p><b>METHODS</b>The clinical and pathological data of 185 patients with congenital biliary duct cyst admitted to Chinese PLA General Hospital were analyzed retrospectively.</p><p><b>RESULTS</b>Among 185 patients, twenty-seven cases had carcinomas arising from congenital biliary duct cyst, and the frequency of malignant transformation was 14.6%, which closely related to the age (P < 0.001). The incidences of malignancy for different age groups were 0 for 0-9 age group, 5.1% for 0-19, 9.1% for 20-29, 16.2% for 30-39, 26.7% for 40-49, 33.3% for 50-59, and 50% for over 60, respectively. Six patients had the history of cyst-enterostomy. Abdominal pain, fever, jaundice and weight loss were the main clinical manifestations. Abdominal ultrasonography, CT, MRI or magnetic resonance cholangiopancreatography, MRCP and endoscopic retrograde choledochopancreatography (ERCP) were the main diagnostic methods. For twenty patients (74.1%), a definite diagnosis was made preoperatively, but it's hard to make an early diagnosis. Nine patients (33.3%) underwent curative resection.</p><p><b>CONCLUSIONS</b>Congenital biliary duct cyst is a premalignant lesion, and the incidence of carcinogenesis increases remarkably with age. The most effective method for prevention of carcinogenesis in choledochal cyst is complete excision of choledochal cyst during childhood, and the prognosis is poor for patients with biliary malignancy.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: General Surgery / Tomography, X-Ray Computed / Choledochal Cyst / Retrospective Studies / Cholangiopancreatography, Endoscopic Retrograde / Common Bile Duct Neoplasms / Early Diagnosis / Cholangiopancreatography, Magnetic Resonance / Diagnosis Type of study: Diagnostic study / Observational study / Prognostic study / Screening study Limits: Adolescent / Aged / Child / Child, preschool / Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Surgery Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: General Surgery / Tomography, X-Ray Computed / Choledochal Cyst / Retrospective Studies / Cholangiopancreatography, Endoscopic Retrograde / Common Bile Duct Neoplasms / Early Diagnosis / Cholangiopancreatography, Magnetic Resonance / Diagnosis Type of study: Diagnostic study / Observational study / Prognostic study / Screening study Limits: Adolescent / Aged / Child / Child, preschool / Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Surgery Year: 2005 Type: Article