Increased CD5 + B Cells in Neonatal Infections / 대한면역학회지
Korean Journal of Immunology
;
: 399-406, 1997.
Article
in Korean
| WPRIM
| ID: wpr-30622
ABSTRACT
PURPOSE:
CD5+ B (B1) cell is a subpopulation of B cells and CD5+ B cells constitute a large fraction of B cells in neonates. CD5 B cells are closely related with autoimmune diseases but the roles and functions in neonates are still unknown. The quantitative changes of CD5+ B cells in neonatal infections were examined to investigate the involvement of CDS+ B cells in neonatal immune reaction to general immunologic stimuli such as infections.Methods:
Ten normal neonates and eight neonates with acute febrile diseases were studied. Venous blood was drawn and mononuclear cells were separated by Ficoll-Hypaque. Half was double-stained with FITC-conjugated anti-CD5 and PE-conjugated anti-CD19, and another half with FITC-conjugated anti-CD4 and PE-conjugated anti-CD8. Stained samples were analyzed using fluorescent-activated cell sortor. ...continue...
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoimmune Diseases
/
B-Lymphocytes
Limits:
Humans
/
Infant, Newborn
Language:
Korean
Journal:
Korean Journal of Immunology
Year:
1997
Type:
Article
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