Effects of intragastric administration of formaldehyde on superoxide dismutase activities and malondialdehyde contents in liver of mice / 中华劳动卫生职业病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.</p><p><b>METHODS</b>Thirty ICR mice were randomly divided into 3 groups one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.</p><p><b>RESULTS</b>The activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).</p><p><b>CONCLUSION</b>A certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.</p>