Effect of folic acid in preventing aberrant methylation of fetal endometriosis susceptibility gene HOXA10 / 南方医科大学学报
Journal of Southern Medical University
;
(12): 926-929, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-306437
ABSTRACT
<p><b>OBJECTIVE</b>To detect aberrant methylation in the promoter region of fetal endometriosis susceptibility gene homeobox-10 (HOXA10) in women with and without folic acid supplementation and explore the effect of folic acid in optimizing intrauterine environment.</p><p><b>METHODS</b>Thirty-six cord blood specimens were collected between January, 2010 and December, 2012 from pregnant women with endometriosis, including 22 with folic acid treatment and 15 without. Methylation-specific polymerase chain reaction (MSP) and bisulfite salt modified sequencing (BSP) were employed to detect aberrant methylation of HOXA10 gene in these specimens.</p><p><b>RESULTS</b>The methylation rate of HOXA10 gene differed significantly between pregnant women with endometriosis taking folic acid and those who did (P<0.05).</p><p><b>CONCLUSION</b>Folic acid treatment can significantly reduce the methylation rate of fetal endometriosis susceptibility gene HOXA10.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Promoter Regions, Genetic
/
Homeodomain Proteins
/
DNA Methylation
/
Therapeutic Uses
/
Endometriosis
/
Fetus
/
Folic Acid
/
Genetics
/
Metabolism
Limits:
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2013
Type:
Article
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