Expression and clinical significance of secretory leucocyte protease inhibitor in colon carcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 898-901, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-306444
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of secretory leucocyte protease inhibitor (SLPI) in colon cancer and their clinical significance.</p><p><b>METHODS</b>Immunohistochemistry was performed to detect the SLPI expression in colon cancer tissue microarray. The expression of SLPI was scored by two pathologists and was analyzed using Χ(2) test to explore its influence on the pathologic characteristics of colon carcinoma.</p><p><b>RESULTS</b>SLPI was up-regulated in colon cancer tissue compared to normal mucosa. Overexpression of SLPI protein was correlated with differentiation grade (low differentiation 42.1% vs 57.9%; moderate/well differentiation 2.3% vs 97.7%, TNM stages(III-IV29.4% vs 70.6%;I-II3.1% vs 96.9%), lymph node metastasis (28.6% vs 71.4%) and distant metastasis (84.6% vs 15.4%), but not with patient age or sex.</p><p><b>CONCLUSION</b>SLPI overexpression correlates with aggressive pathologic characteristics of colon cancer and it may server as prognostic factor of colon cancer patients. Further research will be carried out to verify whether SLPI can become a new target for colon cancer treatment.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Immunohistochemistry
/
Colonic Neoplasms
/
Electrophoresis, Microchip
/
Secretory Leukocyte Peptidase Inhibitor
/
Metabolism
/
Neoplasm Staging
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2013
Type:
Article
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