Cytoplasmic expression of P27 protein and its correlation with clinicopathologic features of nasopharyngeal carcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 882-884, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-306448
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the correlation of p27 protein expression in the cytoplasm with the clinicopathologic features of nasopharyngeal carcinoma (NPC).</p><p><b>METHODS</b>Immunohistochemistry was employed to examine P27 protein expression in the cytoplasm of NPC samples and nasopharyngeal (NP) tissue samples. The differential expression of P27 protein between NPCs and NPs and the correlation of cytoplasmic P27 protein expression with the clinicopathologic parameters of NPC patients was analyzed. RESULTS Immunohistochemistry indicated significantly down-regulated t p27 protein expression in NPC tissues compared to that in NP tissues (P=0.047). The reduction of P27 expression was inversely correlated with T classification of NPC (P=0.033). Although cytoplasmic p27 protein expression was not significantly correlated with lymph node metastasis (P=0.157) or clinical stages of NPC (P=0.090), an obvious trend of inverse correlations between them was noted.</p><p><b>CONCLUSION</b>Down-regulated cytoplasmic p27 protein expression may promote the carcinogenesis of NPC and can be an unfavorable prognostic factor for survival of NPC patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Carcinoma
/
Nasopharyngeal Neoplasms
/
Cytoplasm
/
Cyclin-Dependent Kinase Inhibitor p27
/
Metabolism
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2013
Type:
Article
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